“How shall we escape if we neglect such a great salvation?”
The “great salvation” spoken of in Hebrews provokes a variety of reactions. Some who hear it are offended by the message itself. After all, it tells them the very best they can do in this life is of no account to God, and that there is no way to approach the Infinite on anything but his own terms, which turn out to revolve around glorifying a Jewish carpenter rejected and murdered by the world of his day.
You can understand why people might initially find that proposition makes them grind their teeth. It seems like nonsense to them.